Study of the Surface Modified Co0.5Zn0.5Fe2O4 Nanoensembels for Biomedcal Application

Abstract

Single domain magnetic nanomaterials with appropriate size and properties are interest for verity of biomedical and electrical applications such as magnetic hyperthermia, drug delivery, magnetic resonance imaging contrast enhancement, high-frequency electronics and high-density magnetic storage device. The superparamagnetic nanoparticles have their unique property, which can be manipulated and heated by an external ac magnetic field in order to destroy the cancer cells. In order to address this induction heating of MNPs (hyperthermia effect), we have prepared and characterized Co0.5Zn0.5Fe2O4 nano ensembles throughout this research work. This research work deals with the synthesis of Co0.5Zn0.5Fe2O4 magnetic nanoparticles have been prepared using chemical co-precipitation methods. In order to investigate the annealing effects on their various physical properties, the prepared sample have been annealed at 2000C, 4000C, 6000C, 8000C and 10000C and then compared with the as-prepared sample. The XRD pattern of the as-dried and annealed samples exhibit single phase spinel structure with clear diffraction pattern. Enhancement in crystallite size from 7nn to 25nm is observed with the increase in annealing temperature from 2000C to 10000C respectively. VSM study reviled that as-prepared and annealed samples showed superparamegnetic behavior, which was further confirmed by the Mossbauer Spectroscopy. The saturation magnetization values of Co0.5Zn0.5Fe2O4 increased with the increase in annealing temperature, which confirmed that samples possess size and morphology dependent magnetic properties. Mossbauer spectra observed central doublet nature up to annealed sample 6000C and there is no hyperfine magnetic field is confirmed superparamagnetic behavior. The hydrodynamic diameter and the polydispersity index (PDI) were analyzed by DLS system at 370C and found to be between 173 nm and 231nm where PI is overall less than 0.3. For the hyperthermia study the result of induction heating measurements showed that the temperature raised by the 6mg/ml and 4mg/ml were 460C and 430C respectively. It has been seen that the rise in temperature due to the induction heating depends on the particle size and concentration of the nanoparticle. Finally, when coated with chitosan, these nanoparticle show a great ability to response to external field also suitability for biomedical application especially on hyperthermia therapy.